2023
Uchida, N., Stasula, U., Demirci, S., Germino-Watnick, P., Hinds, M., Le, A., Chu, R., Berg, A., Liu, X., Su, L., Wu, X., Krouse, A. E., Linde, N. S., Bonifacino, A., Hong, S. G., Dunbar, C. E., Lanieri, L., Bhat, A., Palchaudhuri, R., . . . Tisdale, J. F. (2023). Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model. Nat Commun, 14(1), 6291. https://doi.org/10.1038/s41467-023-41153-5.
Lam, N., Finney, R., Yang, S., Choi, S., Wu, X., Cutmore, L., Andrade, J., Huang, L., Amatya, C., Cam, M., & Kochenderfer, J. N. (2023). Development of a bicistronic anti-CD19/CD20 CAR construct including abrogation of unexpected nucleic acid sequence deletions. Mol Ther Oncolytics, 30, 132-149.
Kennedy, B. D., Blazkova, J., Justement, J. S., Shi, V., Rai, M. A., Manning, M. R., Praiss, L., Gittens, K., Wender, P. A., Patro, S., Wu, X., Moir, S., & Chun, T. W. (2023). Comprehensive analysis of HIV reservoirs in elite controllers. J Clin Invest, 133(3).
Jenkins, S., Zhang, W., Steinberg, S. M., Nousome, D., Houston, N., Wu, X., Armstrong, T. S., Burton, E., Smart, D. D., Shah, R., Peer, C. J., Mozarsky, B., Arisa, O., Figg, W. D., Mendoza, T. R., Vera, E., Brastianos, P., Carter, S., Gilbert, M. R., . . . Zimmer, A. S. (2023). Phase I Study and Cell-Free DNA Analysis of T-DM1 and Metronomic Temozolomide for Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases. Clin Cancer Res, 29(8), 1450-1459.
Budhu, A., Pehrsson, E. C., He, A., Goyal, L., Kelley, R. K., Dang, H., Xie, C., Monge, C., Tandon, M., Ma, L., Revsine, M., Kuhlman, L., Zhang, K., Baiev, I., Lamm, R., Patel, K., Kleiner, D. E., Hewitt, S. M., Tran, B., . . . Wang, X. W. (2023). Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy. Cell Rep Med, 4(6), 101052.
Botha, J. C., Demirov, D., Gordijn, C., Katusiime, M. G., Bale, M. J., Wu, X., Wells, D., Hughes, S. H., Cotton, M. F., Mellors, J. W., Kearney, M. F., & van Zyl, G. U. (2023). The largest HIV-1-infected T cell clones in children on long-term combination antiretroviral therapy contain solo LTRs. mBio, 14(4), e0111623.
2022
Xiao, Z., Shi, G., Xi, S., Singh, A. K., Willette-Brown, J., Li, X., Zhu, F., Su, L., Wu, X., Schrump, D. S., & Hu, Y. (2022). A TNFR1-UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop. Cell Death Dis, 13(10), 885.
Tian, M., Cheuk, A. T., Wei, J. S., Abdelmaksoud, A., Chou, H. C., Milewski, D., Kelly, M. C., Song, Y. K., Dower, C. M., Li, N., Qin, H., Kim, Y. Y., Wu, J. T., Wen, X., Benzaoui, M., Masih, K. E., Wu, X., Zhang, Z., Badr, S., . . . Khan, J. (2022). An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma. J Clin Invest, 132(16).
Song, N. Y., Li, X., Ma, B., Willette-Brown, J., Zhu, F., Jiang, C., Su, L., Shetty, J., Zhao, Y., Shi, G., Banerjee, S., Wu, X., Tran, B., Nussinov, R., Karin, M., & Hu, Y. (2022). IKKalpha-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines. Proc Natl Acad Sci U S A, 119(6).
Liu, Y., Zhuo, S., Zhou, Y., Ma, L., Sun, Z., Wu, X., Wang, X. W., Gao, B., & Yang, Y. (2022). Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis. J Hepatol, 76(3), 652-664.
Hadrava Vanova, K., Pang, Y., Krobova, L., Kraus, M., Nahacka, Z., Boukalova, S., Pack, S. D., Zobalova, R., Zhu, J., Huynh, T. T., Jochmanova, I., Uher, O., Hubackova, S., Dvorakova, S., Garrett, T. J., Ghayee, H. K., Wu, X., Schuster, B., Knapp, P. E., . . . Pacak, K. (2022). Germline SUCLG2 Variants in Patients With Pheochromocytoma and Paraganglioma. J Natl Cancer Inst, 114(1), 130-138.
Guo, S., Luke, B. T., Henry, A. R., Darko, S., Brandt, L. D., Su, L., Sun, D., Wells, D., Joseph, K. W., Demirov, D., Halvas, E. K., Douek, D. C., Wu, X., Mellors, J. W., & Hughes, S. H. (2022). HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy. PLoS Pathog, 18(8), e1010726.
De Ravin, S. S., Liu, S., Sweeney, C. L., Brault, J., Whiting-Theobald, N., Ma, M., Liu, T., Choi, U., Lee, J., O’Brien, S. A., Quackenbush, P., Estwick, T., Karra, A., Docking, E., Kwatemaa, N., Guo, S., Su, L., Sun, Z., Zhou, S., . . . Wu, X. (2022). Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human X-linked severe combined immunodeficiency. Nat Commun, 13(1), 3710.
Brault, J., Liu, T., Liu, S., Lawson, A., Choi, U., Kozhushko, N., Bzhilyanskaya, V., Pavel-Dinu, M., Meis, R. J., Eckhaus, M. A., Burkett, S. S., Bosticardo, M., Kleinstiver, B. P., Notarangelo, L. D., Lazzarotto, C. R., Tsai, S. Q., Wu, X., Dahl, G. A., Porteus, M. H., . . . De Ravin, S. S. (2022). CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells. Front Immunol, 13, 1067417.
2021
Zhu, F., Willette-Brown, J., Zhang, J., Ferre, E. M. N., Sun, Z., Wu, X., Lionakis, M. S., & Hu, Y. (2021). NLRP3 Inhibition Ameliorates Severe Cutaneous Autoimmune Manifestations in a Mouse Model of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-Like Disease. J Invest Dermatol, 141(6), 1404-1415.
Vannella, K. M., Oguz, C., Stein, S. R., Pittaluga, S., Dikoglu, E., Kanwal, A., Ramelli, S. C., Briese, T., Su, L., Wu, X., Ramos-Benitez, M. J., Perez-Valencia, L. J., Babyak, A., Cha, N. R., Chung, J. Y., Ylaya, K., Madathil, R. J., Saharia, K. K., Scalea, T. M., . . . Chertow, D. S. (2021). Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case. Front Immunol, 12, 779026.
Sweeney, C. L., Pavel-Dinu, M., Choi, U., Brault, J., Liu, T., Koontz, S., Li, L., Theobald, N., Lee, J., Bello, E. A., Wu, X., Meis, R. J., Dahl, G. A., Porteus, M. H., Malech, H. L., & De Ravin, S. S. (2021). Correction of X-CGD patient HSPCs by targeted CYBB cDNA insertion using CRISPR/Cas9 with 53BP1 inhibition for enhanced homology-directed repair. Gene Ther, 28(6), 373-390.
Schaffer, A. A., Dominguez, D. A., Chapman, L. M., Gertz, E. M., Budhu, A., Forgues, M., Chaisaingmongkol, J., Rabibhadana, S., Pupacdi, B., Wu, X., Bayarsaikhan, E., Harris, C. C., Ruchirawat, M., Ruppin, E., & Wang, X. W. (2021). Integration of adeno-associated virus (AAV) into the genomes of most Thai and Mongolian liver cancer patients does not induce oncogenesis. BMC Genomics, 22(1), 814.
Petrick, J. L., Pfeiffer, R. M., Liao, L. M., Abnet, C. C., Wu, X., Gammon, M. D., Vaughan, T. L., & Cook, M. B. (2021). Circulating MicroRNAs in Relation to Esophageal Adenocarcinoma Diagnosis and Survival. Dig Dis Sci.
Mellors, J. W., Guo, S., Naqvi, A., Brandt, L. D., Su, L., Sun, Z., Joseph, K. W., Demirov, D., Halvas, E. K., Butcher, D., Scott, B., Hamilton, A., Heil, M., Karim, B., Wu, X., & Hughes, S. H. (2021). Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas. Sci Adv, 7(42), eabi8795.
Li, N., Torres, M. B., Spetz, M. R., Wang, R., Peng, L., Tian, M., Dower, C. M., Nguyen, R., Sun, M., Tai, C. H., de Val, N., Cachau, R., Wu, X., Hewitt, S. M., Kaplan, R. N., Khan, J., St Croix, B., Thiele, C. J., & Ho, M. (2021). CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Cell Rep Med, 2(6), 100297.
De Ravin, S. S., Brault, J., Meis, R. J., Liu, S., Li, L., Pavel-Dinu, M., Lazzarotto, C. R., Liu, T., Koontz, S. M., Choi, U., Sweeney, C. L., Theobald, N., Lee, G., Clark, A. B., Burkett, S. S., Kleinstiver, B. P., Porteus, M. H., Tsai, S., Kuhns, D. B., . . . Malech, H. L. (2021). Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells. Blood, 137(19), 2598-2608.
Coffin, J. M., Bale, M. J., Wells, D., Guo, S., Luke, B., Zerbato, J. M., Sobolewski, M. D., Sia, T., Shao, W., Wu, X., Maldarelli, F., Kearney, M. F., Mellors, J. W., & Hughes, S. H. (2021). Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy. PLoS Pathog, 17(4), e1009141.
Brault, J., Liu, T. Q., Bello, E. A., Liu, S., Sweeney, C. L., Meis, R. J., Koontz, S., Corsino, C., Choi, U., Vayssiere, G., Bosticardo, M., Dowdell, K. C., Lazzarotto, C. R., Clark, A., Notarangelo, L. D., Ravell, J. C., Lenardo, M. J., Kleinstiver, B. P., Tsai, S., . . . De Ravin, S. S. (2021). CRISPR-targeted MAGT1 insertion restores XMEN patient hematopoietic stem cells and lymphocytes. Blood.
Brandt, L. D., Guo, S., Joseph, K. W., Jacobs, J. L., Naqvi, A., Coffin, J. M., Kearney, M. F., Halvas, E. K., Wu, X., Hughes, S. H., & Mellors, J. W. (2021). Tracking HIV-1-Infected Cell Clones Using Integration Site-Specific qPCR. Viruses, 13(7).
Blondal, T., Gamba, C., Moller Jagd, L., Su, L., Demirov, D., Guo, S., Johnston, C. M., Riising, E. M., Wu, X., Mikkelsen, M. J., Szabova, L., & Mouritzen, P. (2021). Verification of CRISPR editing and finding transgenic inserts by Xdrop indirect sequence capture followed by short- and long-read sequencing. Methods, 191, 68-77.
Bale, M. J., Katusiime, M. G., Wells, D., Wu, X., Spindler, J., Halvas, E. K., Cyktor, J. C., Wiegand, A., Shao, W., Cotton, M. F., Hughes, S. H., Mellors, J. W., Coffin, J. M., Van Zyl, G. U., & Kearney, M. F. (2021). Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children. mBio, 12(2)
2020
Wells, D. W., Guo, S., Shao, W., Bale, M. J., Coffin, J. M., Hughes, S. H., & Wu, X. (2020). An analytical pipeline for identifying and mapping the integration sites of HIV and other retroviruses. BMC Genomics, 21(1), 216.
Timme, C. R., Degorre-Kerbaul, C., McAbee, J. H., Rath, B. H., Wu, X., Camphausen, K., & Tofilon, P. J. (2020). The Olfactory Bulb Provides a Radioresistant Niche for Glioblastoma Cells. Int J Radiat Oncol Biol Phys, 107(1), 194-201.
Mo, G., Wang, H. W., Talleur, A. C., Shahani, S. A., Yates, B., Shalabi, H., Douvas, M. G., Calvo, K. R., Shern, J. F., Chaganti, S., Patrick, K., Song, Y., Fry, T. J., Wu, X., Triplett, B. M., Khan, J., Gardner, R. A., & Shah, N. N. (2020). Diagnostic approach to the evaluation of myeloid malignancies following CAR T-cell therapy in B-cell acute lymphoblastic leukemia. J Immunother Cancer, 8(2).
Liu, J., Tang, W., Budhu, A., Forgues, M., Hernandez, M. O., Candia, J., Kim, Y., Bowman, E. D., Ambs, S., Zhao, Y., Tran, B., Wu, X., Koh, C., Surana, P., Liang, T. J., Guarnera, M., Mann, D., Rajaure, M., Greten, T. F., . . . Wang, X. W. (2020). A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma. Cell.
Li, D., Li, N., Zhang, Y. F., Fu, H., Feng, M., Schneider, D., Su, L., Wu, X., Zhou, J., Mackay, S., Kramer, J., Duan, Z., Yang, H., Kolluri, A., Hummer, A. M., Torres, M. B., Zhu, H., Hall, M. D., Luo, X., . . . Ho, M. (2020). Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice. Gastroenterology, 158(8), 2250-2265 e2220.
Halvas, E. K., Joseph, K. W., Brandt, L. D., Guo, S., Sobolewski, M. D., Jacobs, J. L., Tumiotto, C., Bui, J. K., Cyktor, J. C., Keele, B. F., Morse, G. D., Bale, M. J., Shao, W., Kearney, M. F., Coffin, J. M., Rausch, J. W., Wu, X., Hughes, S. H., & Mellors, J. W. (2020). HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus. J Clin Invest.
Anderson, E. M., Simonetti, F. R., Gorelick, R. J., Hill, S., Gouzoulis, M. A., Bell, J., Rehm, C., Perez, L., Boritz, E., Wu, X., Wells, D., Hughes, S. H., Rao, V., Coffin, J. M., Kearney, M. F., & Maldarelli, F. (2020). Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections. Viruses, 12(2).