Established and emerging technologies are needed by CCR investigators in order to systematically dissect the heterogeneity of cancer in order to gain a better understanding of the causes of invasion, metastasis, and therapy resistance. These coveted technologies have been identified as having the strongest footing among the leading institutions around the world that are focused on Single Cell (SC) genomic analysis. The OSTR is dedicated to providing these groundbreaking technologies to CCR investigators through educational and informational resources designed to introduce users to various scientific methodologies, as well as seminars on current advancements in scientific methods and instrumentation.
Nanopore Sequencing for Single cell and Spatial Applications
Oxford Nanopore Technologies and 10X Genomics provide updates on using long read sequencing for single cell and spatial applications. Technology
BEPS MAI Unit
Heather Kalish, Ph.D., Unit Chief, Micro Analytical Immunochemistry Unit, BEPS, NIBIB. “Microanalytical Immunochemistry- what we do and how we can help!”. Core Spotlight
Proteomics Analysis using Mass Spectrometry
Proteomics Analysis using Mass Spectrometry. Educational
Center for Advanced Tissue Imaging (CAT-I)
This seminar will detail IBEX, RAPID, Ce3D, and other technologies, show examples of their application to various tissues and cancers. Technology
Crosslinking and Limited Proteolysis
Structural Mass Spectrometry related to crosslinking and limited proteolysis mass spectrometry approaches. Educational
Animal Research Services
NIH ORS and NIH CREx Panel Discussion Series. Panel 2: Animal Model Research Services. February 24, 2022. Core Spotlight
Structural Mass Spectrometry
Structural Mass Spectrometry related to crosslinking and limited proteolysis mass spectrometry approaches. Educational
10X Platforms
Pushing the boundaries of Single Cell with Chromium X. Technology
Core Spotlight Seminar
“Biology Goes 3D: Volume Electron Microscopy of Biological Specimens”. Core Spotlight
Core Spotlight Seminar
Mitochondrial Network Formation as a Tissue-Specific Phenomenon in a Mammalian Model of Extreme Metabolism. Core Spotlight
Quantitative Mass Spectrometry
Quantitative mass spectrometry, specifically the global discoveryexperiments in mass spectrometry. Educational
NINDS Viral Production Core
“An Introduction to Viral Vectors and the NINDS Viral Production Core Facility”. Core Spotlight
PTM Mass Spectrometry
PTM mass spectrometry, specifically the analysis of post-translational modifications by mass spectrometry. Educational
NINDS Laboratory of Functional and Molecular Imaging
“Viral Enabled Study of the Neurons and Circuits Underlying the Brain’s Response to Peripheral Injury”. Core Spotlight
Interactome Mass Spectrometry
Interactome mass spectrometry approaches specifically, proximity-dependent biotinylation for mapping protein complexes mass spectrometry. Educational
Core Services: Mass Spectrometry
NIH ORS and NIH Collaborative Research Exchange (CREx) Panel Discussion Series. Panel 1. October 27, 2021. Core Spotlight
Visualizing Cells in 3-D and at the Nanoscale Level
An introduction to focused ion beam scanning electron microscopy (FIB-SEM) as it relates to visualizing cells in 3-D and at the nanoscale level. Educational
Artificial Intelligence Resource (AIR)
Artificial Intelligence (AI) is becoming important for cancer research but is difficult to access for most labs. The CCR has created a new AI Resource (AI) to benefit researchers in the CCR. Technology